2017-07-26 15:41:12Mon Jun 06 2016 13:10:04 GMT+0200 (CEST)
proteinLength
433
geneLength
1299
Gene
Coordinates
3,314,828 → 3,316,129
The protein
Catalyzed reaction/ biological activity
L-homoserine + NAD(P)+ = L-aspartate 4-semialdehyde + NAD(P)H (according to Swiss-Prot)
L-homoserine
The protein
additional information
belongs to the 100 [SW|most abundant proteins] [PubMed|15378759]
Expression and Regulation
Operons
[[this]]
Expression and Regulation
Other regulations
[[this]]
Biological materials
lacZ fusion
pBP312 (in [[protein|pAC5]]), available in [SW|Fabian Commichau]'s lab [Pubmed|27260660]
pGP312 (in [[protein|pAC5]]), available in [SW|Fabian Commichau]'s lab [Pubmed|27260660]
[SW|Categories] containing this gene/protein
[SW|biosynthesis/ acquisition of amino acids], [SW|membrane proteins], [SW|most abundant proteins]
Gene
Coordinates on the chromosome (coding sequence)
3,314,828 -> 3,316,129
Expression and Regulation
Operon
''[[protein|hom]]-[[protein|thrC]]-[[protein|thrB]]'' [Pubmed|12107147]
Expression and Regulation
Regulation
repressed by casamino acids [Pubmed|12107147]
repressed during growth in the presence of branched chain amino acids ([[protein|CodY]]) [Pubmed|24163341]
expressed in the presence of lysine or cysteine ([SW|ThrR]) [Pubmed|27260660]
Expression and Regulation
Regulatory mechanism
[[protein|CodY]]: transcription repression [Pubmed|24163341]
[[protein|TnrA]]: transcription repression [Pubmed|25755103]
[[protein|ThrR]]: transcription repression [Pubmed|27260660]
Expression and Regulation
Additional information
subject to feedback inhibition [http://www.ncbi.nlm.nih.gov/sites/entrez/19258532 PubMed]
belongs to the 100 [SW|most abundant proteins] [PubMed|15378759]